• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to a positioning marker intended to be inserted in tissue. The marker is an elongated object with a longitudinal axis A and with a diameter perpendicular to said longitudinal axis, wherein the diameter is at the most 1,2 mm. The marker further has a predetermined total length LTOT. The marker comprises a plurality of first segments 1 and a plurality of second segments 2, wherein the first and the second segments are arranged alternately after each others. The marker comprises a first material with a density of at least 10 g/cm3, and this material constitute at least 90 % by volume of the marker, and a second material that is magnetic and that constitute at the most 10 % by volume of the marker.
    公开号:SE1150406A1
    申请号:SE1150406
    申请日:2011-05-09
    公开日:2012-11-10
    发明作者:Ingemar Naeslund
    申请人:Ingemar Naeslund；
    IPC主号:
    专利说明:

    10 l5 20 25 30 2 Position markers are used to indicate the location of a tumor in the tissue of a human or animal. These markers slow down the X-rays so much that they give visible results on the monitors where the results from different media are displayed. Gold has a high density of 19.3 g / cms, which makes it advantageous to use gold as a brake for the rays. Pure gold is also softly malleable and is tolerated by the body because it is an inert material. The volume of gold can be limited so that the substance becomes a narrow thread, which in turn means that markers can be inserted into the body through thin needles. This minimizes the risk of bleeding and infections. Such a marker of gold is known from, for example, WO2006 / 004542 A1.
    X-rays that have passed through a body with a diameter of up to 60 cm provide an image of the monitor in that the rays have been braked to varying degrees in different parts of the tissue. If a small position marker of approx. 0.25 - 1.2 mm in the tissue is to be able to affect the image, the X-rays that hit the marker must slow down X-rays to such an extent that it gives contrast differences in the image.
    Markers that are inserted into the tissue of humans or animals remain essentially in the same place for life. It is therefore extra important that the markers do not cause mechanical damage or give rise to allergies or other disease states. However, the marker must be of a sufficient size and have a suitable density to provide a clear image of the marker during an MRI examination.
    The inventor has identified a need for the use of gold position markers, which is related to the difficulty of making them visible on monitors from all media used to determine the spread of the tumors. In order to facilitate that images from computed tomography and magnetic camera can be superimposed correctly, it would be desirable that the position markers are also visible to the magnetic camera. 10 15 20 25 30 3 For example, gold position markers are not visible on magnetic camera images.
    The object of the present invention is thus to provide a position marker which is visible on monitors for the number of media used to optimize the radiation treatment planning. In addition, the marker must meet the requirements of being tolerated by the body and not cause any mechanical damage to the body of the person the marker is inserted into.
    Summary of the Invention The above objects are achieved by the invention defined by the independent claims.
    Preferred embodiments are defined by the dependent claims.
    According to one aspect, the invention relates to a position marker which is intended to be inserted into tissue. The marker is an elongated element with a diameter of not more than 1.2 mm and a predetermined total length LTQT. The marker comprises a number of first segments and a number of second segments, the first and second segments being arranged alternately one after the other.
    The marker comprises a first material having a density of at least 10 g / cm 3, and that this material constitutes at least 90% by volume of the marker, and a second material which is magnetic and which constitutes at most 10% by volume ~ of the marker.
    Brief Description of the Drawings Figure 1 shows a side view of a part of a position marker according to the invention, and Figure 2 shows an entire marker in an extended state. Detailed Description of Preferred Embodiments of the Invention To make the marker visible on monitors during MRI examination, magnetic materials are required in or on the marker. The amount of such material must be adjusted sparingly so that the cursor does not move in the strong magnetic fields of MRI cameras. Patients with markers may undergo magnetic resonance imaging many times during their lifetime.
    Figure 1 shows a side view of a part of a position marker according to the invention. A position marker consists of a number of thicker parts, first segment 1 and a plurality of thinner parts, second segment 2 which connects two thicker parts with each other. A position marker can have a total length of LToT of about 10-30 mm, which can be seen in Figure 2.
    The total length of the cursor can also be shorter or longer. A preferred length is 20 mm. The width ratio between the first segments 1 and the second segments 2 is usually about 6: 1. For example, the first segments 1 have a width B; which is between 0.15 - 0.3 mm and the other segments 2 a width Bg which is between 0.025 - 0.05 mm. In a preferred embodiment, B1 is 0.28 mm and Bg 0.05. In another preferred embodiment, B1 is 0.20 mm and Bg 0.03 mm. In addition, the first segments 1 have, for example, a length L1 which is about 2 mm and the second segments 2, for example, a length Lg which is about 1 mm.
    The position marker is intended to be inserted into tissue, and where the marker is then intended to be visible on different images that are the result of different media being used. The marker is an elongated element with a maximum diameter of 1.2 mm and a predetermined total length LTOT. The marker comprises a number of first segments 1 and a plurality of second segments 2, the first and second segments being arranged alternately one after the other.
    The marker comprises a first material having a density of at least 10 g / cms, and that this material constitutes at least 90% by volume of the marker, and a second material which is magnetic and which does not exceed 10% by volume of the cursor.
    The first material is preferably gold. And the other material is preferably iron. Preferably, the content of the second material in the marker is 0.5% by volume of the second material. In another embodiment the content of the second material is 2.5% by volume, and in yet another embodiment it is 5% by volume.
    The predetermined total length LTOT of the marker is about 10 to 30 mm. Preferably it is 20 mm.
    The body contains iron to a small extent. An alloy or granular mixture of up to 10% by volume of iron in pure gold makes the marker visible on the MRI camera. The marker thus needs to contain to a greater extent a substance or material with a high density in order to be visible in the X-ray.
    The marker's amount of iron exposed to tissue is negligible in relation to the recommended iron intake per day for both children and adults. Other ferromagnetic materials that the body can tolerate, such as magnetite, gadolinium, dysprosium or an alloy of various substances that form a ferromagnetic material, can also be used.
    Iron or another ferromagnetic material is mixed or alloyed with gold. The amount of the ferromagnetic material in the marker must thus be kept low in order to be tolerated by the body, but it must also be kept low so that it does not give rise to the movement of the marker in the tissue due to the strong magnetic field of a magnetic camera.
    When the marker is inserted into tissue, a hollow needle is suitably used. In the part of the tissue where the tumor is or has been, the marker will be pushed out of the needle and entangled into a compact ball. Suitably 10 15 20 25 30 6 the marker is pushed out of the needle by means of a so-called mandrel. The inner diameter of the needle can be adapted to the larger diameter of the marker, ie. width B1 of the first segments. The inner diameter of the needle can also be larger than the width B1 in order to be able to arrange the marker double weight or triple weight inside the needle. The inner diameter of the needle can be 0.44 mm when a marker with a width B1 of 0.20 mm is used, whereby the marker can then be arranged double weight. To prevent the marker from getting caught in the needle, a lubricant that is compatible with the body can be used, eg special silicone approved for implants.
    The percentage mixture of iron in gold can vary around the specified range, but not so much that the functional requirements as above are disturbed.
    The mixture of iron and gold may also contain other substances that are not pathogenic, e.g. radioactive substances for detection during surgery or PET camera examination.
    What has been said above about gold can also be exchanged for other substances that have a high density and are tolerable by the body, for example platinum, silver or an alloy of suitable materials that has a density of at least 10 g / cms.
    The marker is suitably manufactured by a gold wire of suitable diameter, i.e. the diameter constituting the width Bg of the other segments 2 is used. From this gold wire, parts can then be punched out to create the first segments 1.
    The present invention is not limited to the preferred embodiments described above. Various alternatives, modifications and equivalents can be used. The above embodiments are therefore not to be construed as limiting the scope of the invention, as defined by the appended claims.
    权利要求:
    Claims (8)
    [1]
    A position marker for insertion into tissue, the marker being an elongate member having a diameter not exceeding 1.2 mm and a predetermined total length (brother), the marker comprising a plurality of first segments (1) and a plurality of second segments (2 ), the first and second segments being arranged alternately one after the other, characterized in that - the marker comprises a first material having a density of at least 10 g / cms, and that this material constitutes at least 90% by volume of the marker, and - the marker comprises a second material which is magnetic and which constitutes at most 10% by volume of the marker.
    [2]
    2.. Position marker according to claim 1, characterized in that the first material is gold.
    [3]
    3.. Position marker according to Claim 1 or 2, characterized in that the second material is iron.
    [4]
    4.. Position marker according to one of Claims 1 to 5, characterized in that the content of the second material in the marker constitutes 0.5% by volume of the marker.
    [5]
    5.. Position marker according to one of the preceding claims, characterized in that the predetermined total length (LTOT) is between 10 and 30 mm.
    [6]
    6.. Position marker according to one of the preceding claims, characterized in that the predetermined total length (LToT) is preferably 20 mm. 8
    [7]
    Position marker according to one of the preceding claims, characterized in that the first segments are wider than the second segments and in that the first segments (1) have a first width (B1) and the second segments (2) have a second width (Bg). where the ratio of B1 to Bg is 6: 1.
    [8]
    Position marker according to one of the preceding claims, characterized in that the first segments have a width (B1) which is 0.3 mm and the second segments (2) have a width (Bg) which is 0.05 mm.
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    同族专利:
    公开号 | 公开日
    WO2012154116A1|2012-11-15|
    US20140088419A1|2014-03-27|
    JP2014519375A|2014-08-14|
    EP2706946A4|2014-10-29|
    SE535831C2|2013-01-08|
    JP6506352B2|2019-04-24|
    EP2706946B1|2015-10-14|
    JP2017185296A|2017-10-12|
    US9579160B2|2017-02-28|
    CN103764060B|2016-06-29|
    EP2706946A1|2014-03-19|
    PL2706946T3|2016-02-29|
    CN103764060A|2014-04-30|
    引用文献:
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    US10595956B2|2015-11-25|2020-03-24|Camtomsam AB|Marker loading assembly|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    SE1150406A|SE535831C2|2011-05-09|2011-05-09|position Cursor|SE1150406A| SE535831C2|2011-05-09|2011-05-09|position Cursor|
    PL12782438T| PL2706946T3|2011-05-09|2012-05-08|Positioning marker|
    US14/116,573| US9579160B2|2011-05-09|2012-05-08|Positioning marker|
    CN201280022600.7A| CN103764060B|2011-05-09|2012-05-08|Telltale mark|
    EP12782438.1A| EP2706946B1|2011-05-09|2012-05-08|Positioning marker|
    JP2014510276A| JP2014519375A|2011-05-09|2012-05-08|Positioning marker|
    PCT/SE2012/050484| WO2012154116A1|2011-05-09|2012-05-08|Positioning marker|
    JP2017135316A| JP6506352B2|2011-05-09|2017-07-11|Positioning marker|
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